******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= Dynamic_Sex-independent_Output/seqs-sampled ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr1:140808797-140808897 1.0000 100 chr18:16816825-16816925 1.0000 100 chr7:47319964-47320064 1.0000 100 chr15:60929929-60930029 1.0000 100 chr2:132421434-132421534 1.0000 100 chr1:21114977-21115077 1.0000 100 chr12:33363538-33363638 1.0000 100 chrX:57267596-57267696 1.0000 100 chr5:114597552-114597652 1.0000 100 chr16:15984348-15984448 1.0000 100 chr15:81224588-81224688 1.0000 100 chr2:153418382-153418482 1.0000 100 chr11:7052785-7052885 1.0000 100 chr10:6304385-6304485 1.0000 100 chr9:65063195-65063295 1.0000 100 chr11:73042355-73042455 1.0000 100 chr3:10123738-10123838 1.0000 100 chr13:3767889-3767989 1.0000 100 chr6:120141180-120141280 1.0000 100 chr11:49914002-49914102 1.0000 100 chr3:115314999-115315099 1.0000 100 chr12:105644827-10564492 1.0000 100 chr1:65452129-65452229 1.0000 100 chr2:155298309-155298409 1.0000 100 chr9:30952853-30952953 1.0000 100 chr15:75227034-75227134 1.0000 100 chr8:42218563-42218663 1.0000 100 chr3:51176720-51176820 1.0000 100 chr16:93932911-93933011 1.0000 100 chr8:63433375-63433475 1.0000 100 chr4:118173294-118173394 1.0000 100 chr13:35082447-35082547 1.0000 100 chr9:74452161-74452261 1.0000 100 chr1:99667625-99667725 1.0000 100 chr10:121021982-12102208 1.0000 100 chr8:34942214-34942314 1.0000 100 chr11:5409962-5410062 1.0000 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1.0000 100 chr6:148779502-148779602 1.0000 100 chr1:157673933-157674033 1.0000 100 chr15:63995359-63995459 1.0000 100 chr14:61306073-61306173 1.0000 100 chr17:63036658-63036758 1.0000 100 chr3:121387525-121387625 1.0000 100 chr8:46687333-46687433 1.0000 100 chr14:10453314-10453414 1.0000 100 chr11:51729628-51729728 1.0000 100 chr2:44776068-44776168 1.0000 100 chr12:79053343-79053443 1.0000 100 chr13:91363541-91363641 1.0000 100 chr2:71994367-71994467 1.0000 100 chr15:54418430-54418530 1.0000 100 chr9:74180068-74180168 1.0000 100 chr17:31461586-31461686 1.0000 100 chr9:56865389-56865489 1.0000 100 chr5:20266454-20266554 1.0000 100 chr2:32243120-32243220 1.0000 100 chr16:22918685-22918785 1.0000 100 chr10:87365013-87365113 1.0000 100 chr9:106172953-106173053 1.0000 100 chr3:82829636-82829736 1.0000 100 chr16:35456453-35456553 1.0000 100 chr4:34996156-34996256 1.0000 100 chr8:107591942-107592042 1.0000 100 chr5:107550098-107550198 1.0000 100 chr10:5612834-5612934 1.0000 100 chr19:18706450-18706550 1.0000 100 chr10:94605539-94605639 1.0000 100 chr7:107122771-107122871 1.0000 100 chr5:30836904-30837004 1.0000 100 chr16:33058777-33058877 1.0000 100 chr5:37082617-37082717 1.0000 100 chr8:41357698-41357798 1.0000 100 chr8:93395575-93395675 1.0000 100 chr11:4128412-4128512 1.0000 100 chr8:119516035-119516135 1.0000 100 chr19:25696378-25696478 1.0000 100 chr5:64355700-64355800 1.0000 100 chr11:43451820-43451920 1.0000 100 chr3:10173856-10173956 1.0000 100 chr15:59343007-59343107 1.0000 100 chr18:60545189-60545289 1.0000 100 chr7:108152334-108152434 1.0000 100 chr6:149137470-149137570 1.0000 100 chr4:120836120-120836220 1.0000 100 chr4:62384715-62384815 1.0000 100 chr2:116948643-116948743 1.0000 100 chr1:172386414-172386514 1.0000 100 chr7:128951292-128951392 1.0000 100 chr13:102516026-10251612 1.0000 100 chr8:3227373-3227473 1.0000 100 chr13:16372326-16372426 1.0000 100 chr10:70838751-70838851 1.0000 100 chr7:31728945-31729045 1.0000 100 chr13:31438011-31438111 1.0000 100 chr9:74376237-74376337 1.0000 100 chr11:101148588-10114868 1.0000 100 chr6:128484331-128484431 1.0000 100 chr3:127492601-127492701 1.0000 100 chr6:108090852-108090952 1.0000 100 chr3:120902672-120902772 1.0000 100 chr18:33595751-33595851 1.0000 100 chr6:114762350-114762450 1.0000 100 chr10:87369156-87369256 1.0000 100 chr3:129549683-129549783 1.0000 100 chr1:40228797-40228897 1.0000 100 chr10:92884654-92884754 1.0000 100 chr16:8823701-8823801 1.0000 100 chr19:21727046-21727146 1.0000 100 chr12:81986298-81986398 1.0000 100 chr2:167118778-167118878 1.0000 100 chr15:90176768-90176868 1.0000 100 chr4:55762846-55762946 1.0000 100 chr1:172358158-172358258 1.0000 100 chr6:94733471-94733571 1.0000 100 chr3:82838589-82838689 1.0000 100 chr8:87957777-87957877 1.0000 100 chr7:35861556-35861656 1.0000 100 chr4:9010798-9010898 1.0000 100 chr18:76107099-76107199 1.0000 100 chr7:17224358-17224458 1.0000 100 chr10:87359938-87360038 1.0000 100 chr1:83903419-83903519 1.0000 100 chr7:95410418-95410518 1.0000 100 chr6:119865661-119865761 1.0000 100 chr18:33496691-33496791 1.0000 100 chr12:71326445-71326545 1.0000 100 chr4:32333066-32333166 1.0000 100 chr1:133814094-133814194 1.0000 100 chr6:94116020-94116120 1.0000 100 chr8:108292786-108292886 1.0000 100 chr6:136903191-136903291 1.0000 100 chr13:82365245-82365345 1.0000 100 chr15:62048222-62048322 1.0000 100 chrX:135572594-135572694 1.0000 100 chr18:43410095-43410195 1.0000 100 chr4:104645200-104645300 1.0000 100 chr10:87181180-87181280 1.0000 100 chr1:89920662-89920762 1.0000 100 chr13:35053055-35053155 1.0000 100 chr14:41842507-41842607 1.0000 100 chr11:50483000-50483100 1.0000 100 chr19:28731297-28731397 1.0000 100 chr19:40296930-40297030 1.0000 100 chr1:155536761-155536861 1.0000 100 chr4:6189712-6189812 1.0000 100 chr14:18561474-18561574 1.0000 100 chr13:102283252-10228335 1.0000 100 chr16:23187824-23187924 1.0000 100 chr4:104766506-104766606 1.0000 100 chr1:109836152-109836252 1.0000 100 chr19:32621811-32621911 1.0000 100 chr2:6252584-6252684 1.0000 100 chr17:66214083-66214183 1.0000 100 chr10:5724963-5725063 1.0000 100 chr16:32696883-32696983 1.0000 100 chr2:9894426-9894526 1.0000 100 chr12:111458913-11145901 1.0000 100 chr5:42845266-42845366 1.0000 100 chr19:4508473-4508573 1.0000 100 chr7:125858353-125858453 1.0000 100 chr18:39525902-39526002 1.0000 100 chr11:64400534-64400634 1.0000 100 chr7:47513662-47513762 1.0000 100 chr4:96289333-96289433 1.0000 100 chr3:142193085-142193185 1.0000 100 chr8:35685405-35685505 1.0000 100 chr3:10305201-10305301 1.0000 100 chr8:37314585-37314685 1.0000 100 chr3:105542728-105542828 1.0000 100 chr18:65158974-65159074 1.0000 100 chr18:21533683-21533783 1.0000 100 chr10:74958251-74958351 1.0000 100 chr6:23082898-23082998 1.0000 100 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme Dynamic_Sex-independent_Output/seqs-sampled -oc Dynamic_Sex-independent_Output/meme_out -dna -mod anr -nmotifs 3 -minw 6 -maxw 30 -bfile Dynamic_Sex-independent_Output/background -revcomp -nostatus model: mod= anr nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 6 maxw= 30 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 50 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 60000 N= 600 strands: + - sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.262 C 0.238 G 0.238 T 0.262 Background letter frequencies (from Dynamic_Sex-independent_Output/background): A 0.269 C 0.231 G 0.231 T 0.269 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 11 sites = 50 llr = 543 E-value = 1.5e-022 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 64::::42:aa pos.-specific C :1::a9::::: probability G 32::::18a:: matrix T 13aa:15:::: bits 2.1 * 1.9 *** * * 1.7 *** *** 1.5 **** *** Relative 1.3 **** **** Entropy 1.1 **** **** (15.7 bits) 0.8 **** **** 0.6 ********* 0.4 * ********* 0.2 *********** 0.0 ----------- Multilevel AATTCCTGGAA consensus GT AA sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ----------- chr9:106172953-106173053 - 29 2.90e-07 CTTTTACATG AATTCCTGGAA TCAAACGTAG chr2:71994367-71994467 - 50 2.90e-07 CGTAATACAA AATTCCTGGAA TAGTAAAGGC chr8:91552210-91552310 - 46 2.90e-07 GCATCCCTCC AATTCCTGGAA GCCTGGGCAG chr18:65389863-65389963 + 20 2.90e-07 AGGAAGGATG AATTCCTGGAA GTAGAACTGT chrX:57598138-57598238 - 28 2.90e-07 GACAGGTAAG AATTCCTGGAA CTTGCCAGCC chr3:120902672-120902772 - 2 5.80e-07 CAACAATTAA ATTTCCTGGAA A chr3:82829636-82829736 + 3 5.80e-07 CC ATTTCCTGGAA TGTAGATTCC chr12:35674102-35674202 - 81 5.80e-07 AATTAATGG ATTTCCTGGAA AAGCAGAAAA chr6:108086127-108086227 - 64 5.80e-07 AAAAGCTAGA ATTTCCTGGAA AGAGAAACTC chr4:34741369-34741469 + 74 5.80e-07 AAATGGGCAC ATTTCCTGGAA CAAAAAGGTT chr18:65158974-65159074 - 19 8.71e-07 GGAATTTGAG AATTCCAGGAA CTGGGGTCAT chr18:8863957-8864057 + 51 8.71e-07 GGCAGCTACC AATTCCAGGAA TGTGAGCAAC chr16:91829312-91829412 + 19 8.71e-07 TCAATTGTAC AATTCCAGGAA AGTACTCTCC chr12:79053343-79053443 - 62 1.16e-06 CTGTCGGAGA ATTTCCAGGAA GAAATTCAGG chr1:174862274-174862374 + 83 1.16e-06 AAACATGATC ATTTCCAGGAA AAGCAGA chr1:152306030-152306130 + 7 1.16e-06 CTTCCT ATTTCCAGGAA CTGGACACTG chr10:17723933-17724033 - 64 1.16e-06 TCATTGTGAT ATTTCCAGGAA CAGTGCTATG chr13:35053055-35053155 - 50 1.41e-06 TCAATCTAGG AGTTCCTGGAA AGAGGACAAT chr10:87181180-87181280 - 6 1.66e-06 TATCACAGAA GATTCCTGGAA CCTAG chr11:16642311-16642411 - 55 1.66e-06 AAGAATGGTG GATTCCTGGAA TTGTTGACAA chr12:119551833-11955193 - 51 1.66e-06 TTTGTCACCT GATTCCTGGAA AGTAATGATC chr4:62035372-62035472 - 82 2.16e-06 GTAGACTA AGTTCCAGGAA GAACACGCAG chr19:32621811-32621911 + 90 2.66e-06 ACCAGTAGTA GTTTCCAGGAA chr16:23187824-23187924 - 27 2.66e-06 CCTTTGGGGT GTTTCCAGGAA CAGTGCTACG chr16:8823701-8823801 - 46 2.66e-06 CTTAGGTGGA GTTTCCAGGAA AACTATTTAA chr11:115463572-11546367 + 74 3.08e-06 CCAGTCACAC GGTTCCAGGAA AACGGTCTGA chr6:128484331-128484431 + 90 4.60e-06 CACAGGTTCA ACTTCCTGGAA chr2:52227906-52228006 + 20 4.60e-06 CACTTTGTTC AATTCCAAGAA CTCTGAGGAG chr1:54671682-54671782 - 47 6.01e-06 CTGCCAGGCA TTTTCCTGGAA AGGAACAAAG chr17:83469211-83469311 - 54 6.01e-06 TAAAATGGCA TTTTCCTGGAA AGGACTTTTT chr5:38351484-38351584 - 68 6.59e-06 CCCAGGCCCA TATTCCAGGAA GCCTTCTGGT chr13:31438011-31438111 + 41 7.17e-06 GTTATCTGCA GATTCCTAGAA CCACAGAGCT chr5:114597552-114597652 - 43 7.17e-06 CGGAGCCCTG GATTCCTAGAA TGAAGGTGCA chr16:32696883-32696983 + 61 8.31e-06 TGCTGTGAGA AGTTCCAAGAA GCTAACGGCT chr11:55268745-55268845 + 73 8.31e-06 GCAGCACCTG AGTTCCAAGAA GGGGAGGGAC chr4:76608481-76608581 - 41 1.05e-05 CCAAATGCCA AATTCTAGGAA TTGCATGTGG chr1:89920662-89920762 + 44 1.20e-05 CAGGCCCATT GGTTCCTAGAA GAGCACCTCT chr18:16821582-16821682 + 11 1.25e-05 TTGTTGCATA AGTTCTTGGAA GTGTCTGTGA chr13:4467114-4467214 + 34 1.57e-05 CTTTGGTTCC CGTTCCAGGAA GAGTCTCATT chr13:16408469-16408569 - 13 1.66e-05 GTTGAATAAG TATTCCTAGAA CTGCATTCTG chr10:6304385-6304485 + 81 1.74e-05 AAGGGCAGAT ACTTCCGGGAA GATGGCGCC chr18:60376409-60376509 - 69 1.85e-05 TTTAATTGCC TATTCCGGGAA AGATCTGTCT chr2:9894426-9894526 - 8 2.00e-05 TTGTTATGAG AGTTCCGAGAA TCAAAGT chr8:5030395-5030495 - 23 2.12e-05 CAACAATGCA ATTTCTTAGAA GCAATACAAA chr15:7085826-7085926 + 69 2.27e-05 TAAACTCCCT AATTCCTGGTA TCCTTAACCT chr7:17224358-17224458 + 59 2.52e-05 GCTCTGATAG ATTTCTAAGAA ACATGTCTTT chr1:41612548-41612648 + 13 2.52e-05 TAAACAGGAG GCTTCCGGGAA GCATGTCTTG chr5:87804905-87805005 - 7 3.39e-05 TAAAAGATCT GATTCTAAGAA TGACTT chr2:12820737-12820837 + 61 4.12e-05 AGAACTCTCC GTTTCCAGTAA ATGCCACCTG chr5:53385096-53385196 - 59 4.27e-05 AACACAACTG CGTTCTTGGAA CCTGCTTTGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:106172953-106173053 2.9e-07 28_[-1]_61 chr2:71994367-71994467 2.9e-07 49_[-1]_40 chr8:91552210-91552310 2.9e-07 45_[-1]_44 chr18:65389863-65389963 2.9e-07 19_[+1]_70 chrX:57598138-57598238 2.9e-07 27_[-1]_62 chr3:120902672-120902772 5.8e-07 1_[-1]_88 chr3:82829636-82829736 5.8e-07 2_[+1]_87 chr12:35674102-35674202 5.8e-07 80_[-1]_9 chr6:108086127-108086227 5.8e-07 63_[-1]_26 chr4:34741369-34741469 5.8e-07 73_[+1]_16 chr18:65158974-65159074 8.7e-07 18_[-1]_71 chr18:8863957-8864057 8.7e-07 50_[+1]_39 chr16:91829312-91829412 8.7e-07 18_[+1]_71 chr12:79053343-79053443 1.2e-06 61_[-1]_28 chr1:174862274-174862374 1.2e-06 82_[+1]_7 chr1:152306030-152306130 1.2e-06 6_[+1]_83 chr10:17723933-17724033 1.2e-06 63_[-1]_26 chr13:35053055-35053155 1.4e-06 49_[-1]_40 chr10:87181180-87181280 1.7e-06 5_[-1]_84 chr11:16642311-16642411 1.7e-06 54_[-1]_35 chr12:119551833-11955193 1.7e-06 50_[-1]_39 chr4:62035372-62035472 2.2e-06 81_[-1]_8 chr19:32621811-32621911 2.7e-06 89_[+1] chr16:23187824-23187924 2.7e-06 26_[-1]_63 chr16:8823701-8823801 2.7e-06 45_[-1]_44 chr11:115463572-11546367 3.1e-06 73_[+1]_16 chr6:128484331-128484431 4.6e-06 89_[+1] chr2:52227906-52228006 4.6e-06 19_[+1]_70 chr1:54671682-54671782 6e-06 46_[-1]_43 chr17:83469211-83469311 6e-06 53_[-1]_36 chr5:38351484-38351584 6.6e-06 67_[-1]_22 chr13:31438011-31438111 7.2e-06 40_[+1]_49 chr5:114597552-114597652 7.2e-06 42_[-1]_47 chr16:32696883-32696983 8.3e-06 60_[+1]_29 chr11:55268745-55268845 8.3e-06 72_[+1]_17 chr4:76608481-76608581 1e-05 40_[-1]_49 chr1:89920662-89920762 1.2e-05 43_[+1]_46 chr18:16821582-16821682 1.3e-05 10_[+1]_79 chr13:4467114-4467214 1.6e-05 33_[+1]_56 chr13:16408469-16408569 1.7e-05 12_[-1]_77 chr10:6304385-6304485 1.7e-05 80_[+1]_9 chr18:60376409-60376509 1.8e-05 68_[-1]_21 chr2:9894426-9894526 2e-05 7_[-1]_82 chr8:5030395-5030495 2.1e-05 22_[-1]_67 chr15:7085826-7085926 2.3e-05 68_[+1]_21 chr7:17224358-17224458 2.5e-05 58_[+1]_31 chr1:41612548-41612648 2.5e-05 12_[+1]_77 chr5:87804905-87805005 3.4e-05 6_[-1]_83 chr2:12820737-12820837 4.1e-05 60_[+1]_29 chr5:53385096-53385196 4.3e-05 58_[-1]_31 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=11 seqs=50 chr9:106172953-106173053 ( 29) AATTCCTGGAA 1 chr2:71994367-71994467 ( 50) AATTCCTGGAA 1 chr8:91552210-91552310 ( 46) AATTCCTGGAA 1 chr18:65389863-65389963 ( 20) AATTCCTGGAA 1 chrX:57598138-57598238 ( 28) AATTCCTGGAA 1 chr3:120902672-120902772 ( 2) ATTTCCTGGAA 1 chr3:82829636-82829736 ( 3) ATTTCCTGGAA 1 chr12:35674102-35674202 ( 81) ATTTCCTGGAA 1 chr6:108086127-108086227 ( 64) ATTTCCTGGAA 1 chr4:34741369-34741469 ( 74) ATTTCCTGGAA 1 chr18:65158974-65159074 ( 19) AATTCCAGGAA 1 chr18:8863957-8864057 ( 51) AATTCCAGGAA 1 chr16:91829312-91829412 ( 19) AATTCCAGGAA 1 chr12:79053343-79053443 ( 62) ATTTCCAGGAA 1 chr1:174862274-174862374 ( 83) ATTTCCAGGAA 1 chr1:152306030-152306130 ( 7) ATTTCCAGGAA 1 chr10:17723933-17724033 ( 64) ATTTCCAGGAA 1 chr13:35053055-35053155 ( 50) AGTTCCTGGAA 1 chr10:87181180-87181280 ( 6) GATTCCTGGAA 1 chr11:16642311-16642411 ( 55) GATTCCTGGAA 1 chr12:119551833-11955193 ( 51) GATTCCTGGAA 1 chr4:62035372-62035472 ( 82) AGTTCCAGGAA 1 chr19:32621811-32621911 ( 90) GTTTCCAGGAA 1 chr16:23187824-23187924 ( 27) GTTTCCAGGAA 1 chr16:8823701-8823801 ( 46) GTTTCCAGGAA 1 chr11:115463572-11546367 ( 74) GGTTCCAGGAA 1 chr6:128484331-128484431 ( 90) ACTTCCTGGAA 1 chr2:52227906-52228006 ( 20) AATTCCAAGAA 1 chr1:54671682-54671782 ( 47) TTTTCCTGGAA 1 chr17:83469211-83469311 ( 54) TTTTCCTGGAA 1 chr5:38351484-38351584 ( 68) TATTCCAGGAA 1 chr13:31438011-31438111 ( 41) GATTCCTAGAA 1 chr5:114597552-114597652 ( 43) GATTCCTAGAA 1 chr16:32696883-32696983 ( 61) AGTTCCAAGAA 1 chr11:55268745-55268845 ( 73) AGTTCCAAGAA 1 chr4:76608481-76608581 ( 41) AATTCTAGGAA 1 chr1:89920662-89920762 ( 44) GGTTCCTAGAA 1 chr18:16821582-16821682 ( 11) AGTTCTTGGAA 1 chr13:4467114-4467214 ( 34) CGTTCCAGGAA 1 chr13:16408469-16408569 ( 13) TATTCCTAGAA 1 chr10:6304385-6304485 ( 81) ACTTCCGGGAA 1 chr18:60376409-60376509 ( 69) TATTCCGGGAA 1 chr2:9894426-9894526 ( 8) AGTTCCGAGAA 1 chr8:5030395-5030495 ( 23) ATTTCTTAGAA 1 chr15:7085826-7085926 ( 69) AATTCCTGGTA 1 chr7:17224358-17224458 ( 59) ATTTCTAAGAA 1 chr1:41612548-41612648 ( 13) GCTTCCGGGAA 1 chr5:87804905-87805005 ( 7) GATTCTAAGAA 1 chr2:12820737-12820837 ( 61) GTTTCCAGTAA 1 chr5:53385096-53385196 ( 59) CGTTCTTGGAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 11 n= 54000 bayes= 10.5659 E= 1.5e-022 116 -253 17 -143 57 -194 -21 34 -1229 -1229 -1229 189 -1229 -1229 -1229 189 -1229 211 -1229 -1229 -1229 193 -1229 -116 64 -1229 -153 89 -29 -1229 176 -1229 -1229 -1229 208 -375 186 -1229 -1229 -375 189 -1229 -1229 -1229 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 11 nsites= 50 E= 1.5e-022 0.600000 0.040000 0.260000 0.100000 0.400000 0.060000 0.200000 0.340000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.880000 0.000000 0.120000 0.420000 0.000000 0.080000 0.500000 0.220000 0.000000 0.780000 0.000000 0.000000 0.000000 0.980000 0.020000 0.980000 0.000000 0.000000 0.020000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [AG][ATG]TTCC[TA][GA]GAA -------------------------------------------------------------------------------- Time 40.85 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 15 sites = 22 llr = 310 E-value = 1.3e-014 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :a:9:8:816:8:8: pos.-specific C a:9:82a28:9181a probability G ::::::::14:11:: matrix T ::112:::::1:1:: bits 2.1 * * 1.9 * * * 1.7 ** * * 1.5 *** * * * Relative 1.3 **** ** * * * Entropy 1.1 ********* * *** (20.4 bits) 0.8 *************** 0.6 *************** 0.4 *************** 0.2 *************** 0.0 --------------- Multilevel CACACACACACACAC consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- --------------- chr5:20266454-20266554 + 27 8.26e-10 AACAAACATA CACACACACACACAC ACAAAACAAA chr16:92401330-92401430 + 47 8.26e-10 CACACACACA CACACACACACACAC ACACACACAC chr16:92401330-92401430 + 23 8.26e-10 TTAATCCCTA CACACACACACACAC ACACACACAC chr15:36890272-36890372 + 70 8.26e-10 TTCATTTGCA CACACACACACACAC ACACACACAC chr6:23639731-23639831 + 2 8.26e-10 A CACACACACACACAC ACGGTTGGCA chr6:120141180-120141280 + 76 8.26e-10 CACACACACA CACACACACACACAC CATGAGACAG chr6:120141180-120141280 + 48 8.26e-10 ACTTCCATCA CACACACACACACAC ACACACACAC chr10:10566512-10566612 + 66 3.92e-08 TGGACTGAGT AACACACACACACAC AGTAGTCCCA chr2:92286381-92286481 + 3 1.72e-07 TT CACACACAGACACTC CTTAGTGCAC chr3:148832361-148832461 + 68 1.87e-07 CCTCCGTATG CACACACCCACGCCC AGGCCCTGTC chr16:92697552-92697652 + 64 2.41e-07 GCCGACCCCG CACCCACAGGCACAC GCTGCCATGT chr1:172352354-172352454 + 73 3.07e-07 GACAATCCCC CACAGACACGCCCAC AGGCTGATCT chr11:97163403-97163503 + 56 4.19e-07 TTCACACAAC CACTCCCACATACAC TCAGAGGCCT chr19:30185812-30185912 + 63 4.19e-07 TGAGGGACCT CACATCCAAGCACAC AACTGAACAA chr9:78368686-78368786 + 58 5.25e-07 ATCCTGCAAA CACACACCGGCATAC TGGTTGGTAA chr14:70737540-70737640 - 73 8.13e-07 CAAAAGGCTG CAGATACACATACAC GGCAGTGTGC chr4:57150751-57150851 + 67 9.51e-07 TCGAGGCCAC CATATACAAGCACAC CCACCCTGGG chr9:111020819-111020919 + 60 1.08e-06 CTCCCGGCGC CACACTCCCGCAGAC TCTGTCCTCA chr1:89920662-89920762 + 77 1.53e-06 CCAACCCTCC CACACACCCTCGCCC CCACCCCCA chr4:57126783-57126883 + 42 1.86e-06 GTTCACAGTA CATATACACATACCC TCGAGAAGAA chr2:164258106-164258206 - 15 2.68e-06 GCTGGCTCCC CACTCCCACGCGTAC CAAGCACTCT chr16:92697552-92697652 + 45 4.52e-06 CCCCAGCTCC CGCACCCACGCCGAC CCCGCACCCA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr5:20266454-20266554 8.3e-10 26_[+2]_59 chr16:92401330-92401430 8.3e-10 22_[+2]_9_[+2]_39 chr15:36890272-36890372 8.3e-10 69_[+2]_16 chr6:23639731-23639831 8.3e-10 1_[+2]_84 chr6:120141180-120141280 8.3e-10 47_[+2]_13_[+2]_10 chr10:10566512-10566612 3.9e-08 65_[+2]_20 chr2:92286381-92286481 1.7e-07 2_[+2]_83 chr3:148832361-148832461 1.9e-07 67_[+2]_18 chr16:92697552-92697652 2.4e-07 44_[+2]_4_[+2]_22 chr1:172352354-172352454 3.1e-07 72_[+2]_13 chr11:97163403-97163503 4.2e-07 55_[+2]_30 chr19:30185812-30185912 4.2e-07 62_[+2]_23 chr9:78368686-78368786 5.2e-07 57_[+2]_28 chr14:70737540-70737640 8.1e-07 72_[-2]_13 chr4:57150751-57150851 9.5e-07 66_[+2]_19 chr9:111020819-111020919 1.1e-06 59_[+2]_26 chr1:89920662-89920762 1.5e-06 76_[+2]_9 chr4:57126783-57126883 1.9e-06 41_[+2]_44 chr2:164258106-164258206 2.7e-06 14_[-2]_71 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=15 seqs=22 chr5:20266454-20266554 ( 27) CACACACACACACAC 1 chr16:92401330-92401430 ( 47) CACACACACACACAC 1 chr16:92401330-92401430 ( 23) CACACACACACACAC 1 chr15:36890272-36890372 ( 70) CACACACACACACAC 1 chr6:23639731-23639831 ( 2) CACACACACACACAC 1 chr6:120141180-120141280 ( 76) CACACACACACACAC 1 chr6:120141180-120141280 ( 48) CACACACACACACAC 1 chr10:10566512-10566612 ( 66) AACACACACACACAC 1 chr2:92286381-92286481 ( 3) CACACACAGACACTC 1 chr3:148832361-148832461 ( 68) CACACACCCACGCCC 1 chr16:92697552-92697652 ( 64) CACCCACAGGCACAC 1 chr1:172352354-172352454 ( 73) CACAGACACGCCCAC 1 chr11:97163403-97163503 ( 56) CACTCCCACATACAC 1 chr19:30185812-30185912 ( 63) CACATCCAAGCACAC 1 chr9:78368686-78368786 ( 58) CACACACCGGCATAC 1 chr14:70737540-70737640 ( 73) CAGATACACATACAC 1 chr4:57150751-57150851 ( 67) CATATACAAGCACAC 1 chr9:111020819-111020919 ( 60) CACACTCCCGCAGAC 1 chr1:89920662-89920762 ( 77) CACACACCCTCGCCC 1 chr4:57126783-57126883 ( 42) CATATACACATACCC 1 chr2:164258106-164258206 ( 15) CACTCCCACGCGTAC 1 chr16:92697552-92697652 ( 45) CGCACCCACGCCGAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 15 n= 51600 bayes= 12.7289 E= 1.3e-014 -256 205 -1110 -1110 183 -1110 -234 -1110 -1110 190 -234 -156 168 -234 -1110 -156 -1110 174 -234 -56 152 -35 -1110 -256 -1110 211 -1110 -1110 160 -35 -1110 -1110 -156 174 -76 -1110 113 -1110 65 -256 -1110 190 -1110 -98 152 -134 -76 -1110 -1110 182 -134 -156 160 -76 -1110 -256 -1110 211 -1110 -1110 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 15 nsites= 22 E= 1.3e-014 0.045455 0.954545 0.000000 0.000000 0.954545 0.000000 0.045455 0.000000 0.000000 0.863636 0.045455 0.090909 0.863636 0.045455 0.000000 0.090909 0.000000 0.772727 0.045455 0.181818 0.772727 0.181818 0.000000 0.045455 0.000000 1.000000 0.000000 0.000000 0.818182 0.181818 0.000000 0.000000 0.090909 0.772727 0.136364 0.000000 0.590909 0.000000 0.363636 0.045455 0.000000 0.863636 0.000000 0.136364 0.772727 0.090909 0.136364 0.000000 0.000000 0.818182 0.090909 0.090909 0.818182 0.136364 0.000000 0.045455 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- CACACACAC[AG]CACAC -------------------------------------------------------------------------------- Time 72.07 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 13 sites = 23 llr = 281 E-value = 2.2e-003 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A 989a6999a3aaa pos.-specific C 1:::41:::2::: probability G :::::::::1::: matrix T :21:::11:3::: bits 2.1 1.9 * * 1.7 * * *** 1.5 * * *** *** Relative 1.3 * ** **** *** Entropy 1.1 **** **** *** (17.6 bits) 0.8 ********* *** 0.6 ********* *** 0.4 ********* *** 0.2 ************* 0.0 ------------- Multilevel AAAAAAAAAAAAA consensus T C T sequence C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ------------- chr3:132307004-132307104 - 63 7.72e-08 CCAAAAAAAA AAAAAAAAAAAAA TACACAAAGC chr19:40295294-40295394 + 68 7.72e-08 AAAAAGGGGG AAAAAAAAAAAAA CAGGCTGCTC chr2:165745124-165745224 - 33 7.72e-08 CAACTCTTGG AAAAAAAAAAAAA GCTTAGAACA chr2:153418382-153418482 - 64 7.72e-08 TCTCAAACTT AAAAAAAAAAAAA GAGAGAGAGA chr8:69111278-69111378 + 55 1.77e-07 AATCCCCAAC AAAACAAAATAAA TAGATTAGTA chr5:20266454-20266554 + 44 2.05e-07 ACACACACAC AAAACAAAACAAA ACCAGTGGAC chr19:40295294-40295394 + 4 2.05e-07 AAC AAAACAAAACAAA CAAAACCGCT chr16:23056210-23056310 - 52 2.05e-07 TTCAATGAAC AAAACAAAACAAA AGAACCTGAA chr7:73058059-73058159 + 22 3.16e-07 CATCCTGCCA ATAAAAAAATAAA GAGGAAAAAG chr17:28702065-28702165 + 5 3.44e-07 TTGC AAAACAAAAGAAA TGCCACACAA chr10:88193780-88193880 - 20 4.44e-07 CGCCACAACT ATAACAAAAAAAA ATTTAAGACA chr4:34996156-34996256 - 5 9.22e-07 CTCAGAAACA AAAAACAAACAAA CAAA chr7:26195867-26195967 + 75 9.22e-07 ATTTTCTCAG AAAAACAAACAAA CAAAAAATAG chrX:135572594-135572694 + 81 1.44e-06 TCAATCTAGG AAAACAATAAAAA TTGTGGC chr6:141296431-141296531 + 79 1.59e-06 TCTTATTTTT AACAAAAAAAAAA TGCTGTAAT chr8:131003311-131003411 + 32 1.89e-06 TAACAGGTTG AAAAAAAAATAGA CTGAACCAAA chr10:107883097-10788319 + 87 2.91e-06 GTTTTAATGA ATTAAAAAAAAAA C chr2:67719756-67719856 - 77 3.18e-06 CATGGAACTG CAAACAAAAGAAA CTTTCCCTAA chr13:31314764-31314864 + 15 4.43e-06 ATACTGTATA ATACAAAAATAAA TATGGTATCA chr16:13330292-13330392 + 54 6.75e-06 TGGAAATGTA CAAACATAATAAA CACTGTTCTT chr10:94823746-94823846 + 83 9.47e-06 CCATATCGTG AAAAATATATAAA TATTG chr18:42950125-42950225 - 13 1.02e-05 GAGAAACATG AATAAAAAATAAT CACTTATTGT chr12:84958860-84958960 - 9 1.69e-05 CATATGATAG ATAATATAATAAA TTGATAGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr3:132307004-132307104 7.7e-08 62_[-3]_25 chr19:40295294-40295394 2.1e-07 3_[+3]_51_[+3]_20 chr2:165745124-165745224 7.7e-08 32_[-3]_55 chr2:153418382-153418482 7.7e-08 63_[-3]_24 chr8:69111278-69111378 1.8e-07 54_[+3]_33 chr5:20266454-20266554 2.1e-07 43_[+3]_44 chr16:23056210-23056310 2.1e-07 51_[-3]_36 chr7:73058059-73058159 3.2e-07 21_[+3]_66 chr17:28702065-28702165 3.4e-07 4_[+3]_83 chr10:88193780-88193880 4.4e-07 19_[-3]_68 chr4:34996156-34996256 9.2e-07 4_[-3]_83 chr7:26195867-26195967 9.2e-07 74_[+3]_13 chrX:135572594-135572694 1.4e-06 80_[+3]_7 chr6:141296431-141296531 1.6e-06 78_[+3]_9 chr8:131003311-131003411 1.9e-06 31_[+3]_56 chr10:107883097-10788319 2.9e-06 86_[+3]_1 chr2:67719756-67719856 3.2e-06 76_[-3]_11 chr13:31314764-31314864 4.4e-06 14_[+3]_73 chr16:13330292-13330392 6.8e-06 53_[+3]_34 chr10:94823746-94823846 9.5e-06 82_[+3]_5 chr18:42950125-42950225 1e-05 12_[-3]_75 chr12:84958860-84958960 1.7e-05 8_[-3]_79 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=13 seqs=23 chr3:132307004-132307104 ( 63) AAAAAAAAAAAAA 1 chr19:40295294-40295394 ( 68) AAAAAAAAAAAAA 1 chr2:165745124-165745224 ( 33) AAAAAAAAAAAAA 1 chr2:153418382-153418482 ( 64) AAAAAAAAAAAAA 1 chr8:69111278-69111378 ( 55) AAAACAAAATAAA 1 chr5:20266454-20266554 ( 44) AAAACAAAACAAA 1 chr19:40295294-40295394 ( 4) AAAACAAAACAAA 1 chr16:23056210-23056310 ( 52) AAAACAAAACAAA 1 chr7:73058059-73058159 ( 22) ATAAAAAAATAAA 1 chr17:28702065-28702165 ( 5) AAAACAAAAGAAA 1 chr10:88193780-88193880 ( 20) ATAACAAAAAAAA 1 chr4:34996156-34996256 ( 5) AAAAACAAACAAA 1 chr7:26195867-26195967 ( 75) AAAAACAAACAAA 1 chrX:135572594-135572694 ( 81) AAAACAATAAAAA 1 chr6:141296431-141296531 ( 79) AACAAAAAAAAAA 1 chr8:131003311-131003411 ( 32) AAAAAAAAATAGA 1 chr10:107883097-10788319 ( 87) ATTAAAAAAAAAA 1 chr2:67719756-67719856 ( 77) CAAACAAAAGAAA 1 chr13:31314764-31314864 ( 15) ATACAAAAATAAA 1 chr16:13330292-13330392 ( 54) CAAACATAATAAA 1 chr10:94823746-94823846 ( 83) AAAAATATATAAA 1 chr18:42950125-42950225 ( 13) AATAAAAAATAAT 1 chr12:84958860-84958960 ( 9) ATAATATAATAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 13 n= 52800 bayes= 11.5668 E= 2.2e-003 176 -141 -1117 -1117 154 -1117 -1117 -31 169 -241 -1117 -163 183 -241 -1117 -1117 107 76 -1117 -263 169 -141 -1117 -263 176 -1117 -1117 -163 176 -1117 -1117 -163 189 -1117 -1117 -1117 37 -9 -141 37 189 -1117 -1117 -1117 183 -1117 -241 -1117 183 -1117 -1117 -263 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 13 nsites= 23 E= 2.2e-003 0.913043 0.086957 0.000000 0.000000 0.782609 0.000000 0.000000 0.217391 0.869565 0.043478 0.000000 0.086957 0.956522 0.043478 0.000000 0.000000 0.565217 0.391304 0.000000 0.043478 0.869565 0.086957 0.000000 0.043478 0.913043 0.000000 0.000000 0.086957 0.913043 0.000000 0.000000 0.086957 1.000000 0.000000 0.000000 0.000000 0.347826 0.217391 0.086957 0.347826 1.000000 0.000000 0.000000 0.000000 0.956522 0.000000 0.043478 0.000000 0.956522 0.000000 0.000000 0.043478 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- A[AT]AA[AC]AAAA[ATC]AAA -------------------------------------------------------------------------------- Time 102.89 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:140808797-140808897 9.68e-01 100 chr18:16816825-16816925 6.58e-02 57_[-1(6.36e-05)]_32 chr7:47319964-47320064 9.38e-01 100 chr15:60929929-60930029 5.75e-02 86_[-1(6.36e-05)]_3 chr2:132421434-132421534 5.95e-01 100 chr1:21114977-21115077 2.13e-01 100 chr12:33363538-33363638 9.82e-01 100 chrX:57267596-57267696 6.48e-01 100 chr5:114597552-114597652 1.86e-02 42_[-1(7.17e-06)]_47 chr16:15984348-15984448 6.62e-01 100 chr15:81224588-81224688 9.65e-01 100 chr2:153418382-153418482 5.22e-04 63_[-3(7.72e-08)]_24 chr11:7052785-7052885 4.75e-02 100 chr10:6304385-6304485 4.10e-03 80_[+1(1.74e-05)]_9 chr9:65063195-65063295 8.95e-01 100 chr11:73042355-73042455 9.67e-01 100 chr3:10123738-10123838 9.08e-01 100 chr13:3767889-3767989 7.43e-02 100 chr6:120141180-120141280 6.87e-06 45_[+2(8.26e-10)]_1_[+2(8.26e-10)]_\ 1_[+2(1.30e-05)]_8 chr11:49914002-49914102 5.00e-01 100 chr3:115314999-115315099 9.72e-02 77_[+1(3.52e-05)]_12 chr12:105644827-10564492 2.70e-02 60_[-2(3.81e-05)]_25 chr1:65452129-65452229 6.76e-02 100 chr2:155298309-155298409 7.84e-01 100 chr9:30952853-30952953 2.19e-01 100 chr15:75227034-75227134 1.75e-01 100 chr8:42218563-42218663 4.06e-02 31_[+2(6.29e-05)]_54 chr3:51176720-51176820 4.33e-01 100 chr16:93932911-93933011 8.53e-01 100 chr8:63433375-63433475 9.97e-01 100 chr4:118173294-118173394 9.74e-01 100 chr13:35082447-35082547 6.56e-01 100 chr9:74452161-74452261 2.00e-01 100 chr1:99667625-99667725 3.08e-01 100 chr10:121021982-12102208 1.62e-01 100 chr8:34942214-34942314 3.76e-01 100 chr11:5409962-5410062 4.75e-01 100 chr5:123220677-123220777 1.45e-01 100 chr14:121650870-12165097 4.95e-02 18_[-1(3.22e-05)]_71 chr4:9172702-9172802 2.11e-01 100 chr17:83469211-83469311 7.81e-04 53_[-1(6.01e-06)]_36 chr19:47412065-47412165 2.11e-02 45_[-1(4.57e-05)]_44 chr15:58823951-58824051 5.71e-02 33_[+2(2.29e-05)]_52 chr18:11144597-11144697 3.57e-01 100 chr4:53608929-53609029 5.23e-02 5_[+3(2.91e-05)]_82 chr4:141129499-141129599 4.08e-01 100 chr6:38773819-38773919 7.59e-01 100 chr6:135963650-135963750 7.87e-01 100 chr15:62054215-62054315 3.53e-02 35_[-2(9.12e-05)]_50 chr9:114640096-114640196 4.22e-01 100 chr4:104057852-104057952 3.96e-01 100 chr11:112601025-11260112 8.13e-03 2_[-1(9.61e-06)]_87 chr8:10936630-10936730 4.55e-01 100 chr4:134797647-134797747 1.32e-01 100 chr16:91784526-91784626 8.15e-01 100 chr2:157888534-157888634 7.91e-01 100 chr19:14816790-14816890 2.90e-01 100 chr14:63722778-63722878 4.85e-02 71_[+1(3.52e-05)]_18 chr9:48606674-48606774 7.82e-01 100 chr14:31719062-31719162 7.55e-01 100 chr2:109799156-109799256 9.87e-01 100 chr4:34741369-34741469 3.10e-04 73_[+1(5.80e-07)]_16 chr2:167808245-167808345 4.89e-01 100 chr2:32264275-32264375 2.68e-01 100 chr13:23896289-23896389 3.85e-01 100 chr10:111018771-11101887 9.92e-01 100 chr14:116847410-11684751 3.65e-02 59_[+1(3.05e-05)]_30 chr5:4076246-4076346 8.31e-01 100 chr6:23639731-23639831 1.62e-07 1_[+2(8.26e-10)]_62_[+1(3.22e-05)]_\ 11 chr4:100073998-100074098 3.40e-01 100 chr3:106350444-106350544 6.82e-01 100 chr16:93822124-93822224 1.67e-01 100 chr2:50837946-50838046 4.47e-01 100 chr2:144082497-144082597 4.17e-01 100 chr4:57968726-57968826 4.36e-01 100 chr9:48531815-48531915 3.00e-02 100 chr13:16408469-16408569 4.16e-02 10_[+1(1.41e-05)]_79 chr3:82846274-82846374 3.45e-01 100 chr10:112391107-11239120 7.06e-04 44_[-1(2.52e-05)]_9_[-2(3.27e-05)]_\ 21 chr3:10304293-10304393 3.40e-01 100 chr14:75550632-75550732 1.08e-01 100 chr9:70690032-70690132 2.02e-01 100 chr13:102293377-10229347 2.39e-01 100 chr6:122521249-122521349 8.97e-01 100 chr16:22920197-22920297 5.52e-01 100 chr3:73504479-73504579 6.51e-02 22_[+1(6.36e-05)]_67 chr9:59200249-59200349 1.79e-02 84_[+3(1.08e-05)]_3 chr4:34996739-34996839 7.54e-01 100 chr8:89123248-89123348 6.23e-01 100 chr1:142312145-142312245 5.80e-02 100 chr14:29452141-29452241 9.40e-01 100 chr2:6254890-6254990 5.81e-02 100 chr8:112108795-112108895 3.10e-01 100 chr16:13330292-13330392 3.32e-03 53_[+3(6.75e-06)]_34 chr7:54001460-54001560 1.77e-02 34_[+2(9.74e-05)]_51 chr15:78247320-78247420 8.03e-01 100 chr9:45766157-45766257 4.08e-01 100 chr3:95472699-95472799 2.25e-02 83_[+3(3.17e-05)]_4 chrX:18451118-18451218 9.60e-02 100 chr17:51991975-51992075 4.43e-01 100 chr13:40985850-40985950 4.05e-01 100 chr2:147752599-147752699 7.25e-01 100 chr1:41615981-41616081 1.47e-01 100 chr4:57126783-57126883 8.12e-03 41_[+2(1.86e-06)]_44 chr3:27044596-27044696 4.61e-02 12_[+3(4.63e-05)]_75 chr9:111020819-111020919 6.71e-03 59_[+2(1.08e-06)]_26 chr16:58454668-58454768 5.90e-01 100 chrX:151586343-151586443 7.93e-03 58_[+1(3.84e-05)]_31 chr1:174833427-174833527 4.94e-01 100 chr7:13568570-13568670 5.58e-02 89_[+1(5.78e-05)] chr4:76608481-76608581 4.84e-03 38_[+1(3.42e-06)]_51 chr11:16490483-16490583 1.74e-01 100 chr13:31314764-31314864 5.07e-03 14_[+3(4.43e-06)]_73 chr13:91887619-91887719 9.99e-01 100 chr11:107289404-10728950 2.23e-01 100 chrX:157729775-157729875 3.26e-01 100 chr7:137717974-137718074 2.08e-01 100 chr4:16126546-16126646 5.38e-01 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